Higher Symptom Burden Associated With Increased Health Care Utilization in Patients with Transplant-Ineligible Newly Diagnosed Multiple Myeloma

Patients with transplant-ineligible newly diagnosed multiple myeloma (TI NDMM) are known to have high rates of unplanned health care utilization. However, factors that predict which patients are more likely to have unplanned emergency department (ED) use or hospitalization than others are not known.

Mian et al. investigated the relationship between patient-reported outcomes and subsequent 14-day risk of ED visits and hospitalizations to evaluate whether symptom burden is predictive of health care utilization.

In this retrospective population-based study, validated Edmonton Symptoms Assessment System (ESAS) scores were collected for 2,876 patients with NDMM in Ontario, Canada, and compared to rates of ED use and hospitalization in the 14 days following score obtainment.

An incremental increase in unplanned health care utilization was noted with increasing ESAS scores. Additionally, after controlling for confounding factors, individual symptom scores were positively associated with ED visits and hospitalizations.