Bone Marrow Adipocytes Shape Metabolism and Immunity in Tumor Microenvironment to Promote Multiple Myeloma

Bone marrow adipocytes (BMAs) make up a majority of the bone marrow volume and have unique immunomodulatory properties. However, their role in multiple myeloma (MM) progression remains unknown.

Lingling Shu, MD, PhD and colleagues found that patients with MM had a significantly increased quantity of BMAs compared to healthy controls. Furthermore, the expression of fatty acid-binding protein 4 (FABP4) was significantly increased in BMAs of patients with MM.

Additional analysis of the role of FABP4 in FABP4 knock out mice compared to littermate controls showed differences in metabolism and immunity in the bone marrow microenvironment between the two groups.