Age, Tumor Mutations, and Clonal Hematopoiesis Associated with Racial and Ethnic Disparities in Patients with Multiple Myeloma

Racial and ethnic disparities in treatment and mortality are known to exist for patients with multiple myeloma (MM), however, factors driving these disparities and data specific to Hispanic populations is not well understood.

Gillis et al. investigated demographic, clinical, and molecular features, including tumor mutations and clonal hematopoiesis in 496 patients with multiple myeloma from diverse racial and ethnic backgrounds. Associated outcomes analyzed related to these factors were overall survival and progression-free survival.

Age at diagnosis, tumor mutations, and clonal hematopoiesis were all found to be associated with clinical disparities in this subset of patients with MM.